Journal of Liver Cancer

Geum Youn Gwak

2 Articles

Hepatocellular Carcinoma Invading Bile Duct: Geum Youn Gwak; Journal of the Korean Liver Cancer Study Group. 2008;8(1):1-7. Published online June 30, 2008

Abstract PDF: Although invasion of portal veins and hepatic veins is common in hepatocellular carcinoma (HCC), macroscopic bile duct invasion is rare. Bile duct thrombi have been identified in 0.5% to 9% of HCC patients. In general, these patients have a worse clinical course and shorter survival than patients without bile duct thrombi, probably attributable to the low resectability rate secondary to poor functional reserve caused by obstructive jaundice and cholangitis, and combined major vascular invasion. However, a few data demonstrated that an aggressive operative approach after appropriate preoperative management offered a better chance of long-term survival in some patients with HCC with bile duct thrombi. Herein, we describe some cases of HCC with bile duct thrombi and summarize clinical features and treatment outcomes on the basis of the literatures published to date.

A Case of Combined Hepatocellular-Cholangiocarcinoma Mimicking Focal Nodular Hyperplasia: Dong Hyun Shin, Kwang Cheol Koh, Geum Youn Gwak, Dong Il Choi, Cheol Keun Park, Moon Seok Choi, Joon Hyoek Lee, Seung Woon Paik, Byung Chul Yoo; Journal of the Korean Liver Cancer Study Group. 2007;7(1):55-58. Published online June 30, 2007

Abstract PDF: Combined hepatocellular and cholangiocarcinoma (cHCC-CC) is an uncommon form of primary liver cancer having features of both hepatocellular and billiary epithelial differentiation. We report a case of cHCC-CC in a patient who was serologically positive for hepatitis B virus. A 39-year-old male was diagnosed by ultrasonography with an asymptomatic tumor in the left lobe of the liver. Based on radiologic and serologic findings of elevated serum alpha-fetoprotein level, a preoperative diagnosis of hepatocellular carcinoma was made, but differential diagnosis included focal nodular hyperplasia, because tumor was enhanced in delayed phase in Godolinium MRI scan. A final diagnosis of cHCC-CC was made after operation.